combinatorial chemistry

Prepacked NovoGROM HPLC Columns

dedicated to Combinatorial Chemistry

Combinatorial Chemistry: One of the most advanced, modern technologies requires a broad range in selectivity and excellent stability of stationary phases, while maintaining column durability and efficiency with good peak symmetry, especially for basic and acidic compounds. These important features are only guaranteed by a couple of the commonly available stationary phases such as GROM-SIL phases .

Outstanding Feature and Benefit of unique NovoGROM column hardware:


	Low-dispersion, i.e. no peak broadening by hardware void volume		Extraordinary performance even at high speed, therefore ensuring high sample throughput

			more information about combinatorial chemistry
	to see the picture, please click and open PDF-File		combinatorial chemistry stainless steel columns, prepacked preferably with:
			Guard column cartridges to be used in conjunction with guard column head or guard column holder
			Combinatorial Chemistry low dispersion column hardware
			Down-scaling and UP-scaling for the isolation of drugs

analytical scale

10 or 20 x 4 mm
guard column, cartridge, complete

50 x 4 mm
column with integrated guard column

50 x 4 mm
column for conventional ferrule-type fitting

semi-preparative scale

10 or 20 x 8 mm
guard column cartridge, complete

50 x 8 mm
column with integrated guard column

50 x 8 mm
column for conventional ferrule-type fitting

preparative scale

10 or 20 x 20 mm, resp. x 30 mm
guard column cartridge, complete

50 x 20 mm, resp. x 30 mm
column* with integrated guard column

50 x 20 mm, resp. x 30 mm
column for conventional ferrule-type fitting

	short columns		fast separations
	integrated guard columns		low dispersion, i.e. no peak broadening
	disposable guard column cartridges		cost saving, easy to use
	high versatility		unique flexibility when "up-scaling"
	packed with all commonly available stationary phases		enables optimal selectivity

Combinatorial chemistry stainless steel columns, prepacked preferably with:

Order number	Description
GSODS0511S0502	NovoGROM CombiChem column, 50 x 2.0 mm, packed with GROM- Sapphire (C18 / 5 µm / 110 Å)
GSOD30512S0502	NovoGROM CombiChem column, 50 x 2.0 mm, packed with GROM- SIL 120 ODS-3 CP (C18 / 5 µm / 120 Å)
GSOD40512S0502	NovoGROM CombiChem column, 50 x 2.0 mm, packed with GROM- SIL 120 ODS-4 HE (C18 / 5 µm / 120 Å)

GSODS0511S0504	NovoGROM CombiChem column, 50 x 4.0 mm, packed with GROM- Sapphire (C18 / 5 µm / 110 Å)
GSOD30512S0504	NovoGROM CombiChem column, 50 x 4.0 mm, packed with GROM- SIL 120 ODS-3 CP (C18 / 5 µm / 120 Å)
GSOD40512S0504	NovoGROM CombiChem column, 50 x 4.0 mm, packed with GROM- SIL 120 ODS-4 HE (C18 / 5 µm / 120 Å)

GSODS0511S0508	NovoGROM CombiChem column, 50 x 8 mm, packed with GROM- Sapphire (C18 / 5 µm / 110 Å)
GSOD30512S0508	NovoGROM CombiChem column, 50 x 8 mm, packed with GROM- SIL 120 ODS-3 CP (C18 / 5 µm / 120 Å)
GSOD40512S0508	NovoGROM CombiChem column, 50 x 8 mm, packed with GROM- SIL 120 ODS-4 HE (C18 / 5 µm / 120 Å)

GSODS0511S0520	NovoGROM CombiChem column, 50 x 20 mm, packed with GROM- Sapphire (C18 / 5 µm / 110 Å)
GSOD30512S0520	NovoGROM CombiChem column, 50 x 20 mm, packed with GROM- SIL 120 ODS-3 CP (C18 / 5 µm / 120 Å)
GSOD40512S0520	NovoGROM CombiChem column, 50 x 20 mm, packed with GROM- SIL 120 ODS-4 HE (C18 / 5 µm / 120 Å)

GSODS0511S0530	NovoGROM CombiChem column, 50 x 30 mm, packed with GROM- Sapphire (C18 / 5 µm / 110 Å)
GSOD30512S0530	NovoGROM CombiChem column, 50 x 30 mm, packed with GROM- SIL 120 ODS-3 CP (C18 / 5 µm / 120 Å)
GSOD40512S0530	NovoGROM CombiChem column, 50 x 30 mm, packed with GROM- SIL 120 ODS-4 HE (C18 / 5 µm / 120 Å)

Note !

NovoGROM columns dedicated to Combinatorial Chemistry can be packed with any of the stationary phases of the GROM HPLC 2000 catalogue.

Combinatorial Chemistry low dispersion column hardware : (stainless steel)*

Guard column cartridges to be used in conjunction with

		guard column head or	guard column holder
Order number	Dimensions / Quantity	Order number	Order number
**....V0101V	10 x 1.0 mm (Pk. of 5)	3551	2551
**....V0201V	20 x 1.0 mm (Pk. of 5)	3555	2555
**....V0102V	10 x 2.0 mm (Pk. of 5)	3551	2551
**....V0202V	20 x 2.0 mm (Pk. of 5)	3555	2555
**....V0104V	10 x 4.0 mm (Pk. of 5)	3101	2116
**....V0204V	20 x 4.0 mm (Pk. of 5)	3102	2115
**....V0108V	10 x 8.0 mm (Pk. of 2)	50.3111	50.2111
**....V0208V	20 x 8.0 mm (Pk. of 2)	50.3112	50.2112
**....V0120V	10 x 20 mm (Pk. of 2)	70.3111	70.2111
**....V0220V	20 x 20 mm (Pk. of 2)	70.3112	70.2112
**....V0230V	20 x 30 mm (Pk. of 1)	----	75.2112
**....V0330V	30 x 30 mm (Pk. of 1)	----	75.2113

* Other dimensions upon request.

** Please, add abbreviation for the desired stationary phase.



Combinatorial Chemistry low dispersion column hardware (stainless steel):*

CombiChem cartridge CombiChem column

Order number Order number Dimensions

**....K0401 **....S0401 40 x 1.0 mm

**....K0501 **....S0501 50 x 1.0 mm



**....K0402 **....S0402 40 x 2.0 mm

**....K0502 **....S0502 50 x 2.0 mm



**....K0404 **....S0404 40 x 4.0 mm

**....K0504 **....S0504 50 x 4.0 mm



--- **....S0408 40 x 8.0 mm

--- **....S0508 50 x 8.0 mm



see guard column cartridge **....S0320 30 x 20 mm

--- **....S0420 40 x 20 mm

--- **....S0520 50 x 20 mm



see guard column cartridge **....S0330 30 x 30 mm

--- **....S0430 40 x 30 mm

--- **....S0530 50 x 30 mm



--- **....S0440 40 x 40 mm

--- **....S0540 50 x 40 mm



--- **....S0450 40 x 50 mm

--- **....S0550 50 x 50 mm

* Other dimensions upon request.

** Please, add abbreviation for the desired stationary phase.

Down-scaling and Up-scaling for the isolation of drugs

Column phase:	GROM-SIL 120 ODS-3 CP, 3 µm	Column phase:	GROM-SIL 120 ODS-3 CP, 5 µm	Column phase:	GROM-SIL 120 ODS-3 CP, 5 µm
Column size:	30 x 4.0 mm	Column size:	50 x 4.0 mm	Column size:	50 x 8 mm
Eluent A:	H₂O	Eluent A:	H₂O	Eluent A:	H₂O
B:	ACN	B:	ACN	B:	ACN
Gradient:	10% B (0 -1 min),	Gradient:	10% B (0-2 min),	Gradient:	10% B (0-2 min),
	10-90% B (1-4.2 min),		10-90% B (2-6 min),		10-90% B (2-6 min),
	90% B (4.2-5 min),		90% B (6-7min),		90% B (6-7min),
	90-10% B (5-5.2 min)		90-10% B (7-7.2 min)		90-10% B (7-7.2 min)
Flow rate:	2 ml/min	Flow rate:	2 ml/min	Flow rate:	8 ml/min
Pressure:	13.8 MPa	Pressure:	11.2 MPa	Pressure:	13.2 MPa
Temperature:		Temperature:	RT	Temperature:	RT
Detection (UV):	254 nm	Detection (UV):	254 nm	Detection (UV):	254 nm
Injection:	0.4 mg / 100 µl	Injection:	0.4 mg / 100 µl	Injection:	1.6 mg / 400 µl

CombiChem cartridge	CombiChem column
Order number	Order number	Dimensions
**....K0401	**....S0401	40 x 1.0 mm
**....K0501	**....S0501	50 x 1.0 mm

**....K0402	**....S0402	40 x 2.0 mm
**....K0502	**....S0502	50 x 2.0 mm

**....K0404	**....S0404	40 x 4.0 mm
**....K0504	**....S0504	50 x 4.0 mm

---	**....S0408	40 x 8.0 mm
---	**....S0508	50 x 8.0 mm

see guard column cartridge	**....S0320	30 x 20 mm
---	**....S0420	40 x 20 mm
---	**....S0520	50 x 20 mm

see guard column cartridge	**....S0330	30 x 30 mm
---	**....S0430	40 x 30 mm
---	**....S0530	50 x 30 mm

---	**....S0440	40 x 40 mm
---	**....S0540	50 x 40 mm

---	**....S0450	40 x 50 mm
---	**....S0550	50 x 50 mm